- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2024-05-27 12:37:21+12:00
- Desc:
- Update figures and submodule sedCellML
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b65/rawfile/6625532496cd4d09db3c72278c24fe5ef8cf84cd/Electrogenic cotransporter/CellMLV2/SGLT1_ss_fast.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/2.0#" name="SGLT1_BG">
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="params_ss_fast.cellml">
<component component_ref="params_BG" name="params_BG"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="./units.cellml">
<units units_ref="fmol_per_s" name="fmol_per_s"/>
<units units_ref="C_per_mol" name="C_per_mol"/>
<units units_ref="per_fmol" name="per_fmol"/>
<units units_ref="fmol" name="fmol"/>
<units units_ref="fA" name="fA"/>
<units units_ref="J_per_mol" name="J_per_mol"/>
<units units_ref="J_per_K_mol" name="J_per_K_mol"/>
</import>
<component name="SGLT1_BG">
<variable name="R" units="J_per_K_mol" interface="public"/>
<variable name="T" units="kelvin" interface="public"/>
<variable name="F" units="C_per_mol" interface="public"/>
<variable name="K_Nai" units="per_fmol" interface="public"/>
<variable name="q_Nai" units="fmol" interface="public"/>
<variable name="K_Nao" units="per_fmol" interface="public"/>
<variable name="q_Nao" units="fmol" interface="public"/>
<variable name="K_Glci" units="per_fmol" interface="public"/>
<variable name="q_Glci" units="fmol" interface="public"/>
<variable name="K_Glco" units="per_fmol" interface="public"/>
<variable name="q_Glco" units="fmol" interface="public"/>
<variable name="K_1" units="per_fmol" interface="public"/>
<variable name="q_init_1" units="fmol" interface="public"/>
<variable name="K_2" units="per_fmol" interface="public"/>
<variable name="q_init_2" units="fmol" interface="public"/>
<variable name="K_3" units="per_fmol" interface="public"/>
<variable name="q_init_3" units="fmol" interface="public"/>
<variable name="K_4" units="per_fmol" interface="public"/>
<variable name="q_init_4" units="fmol" interface="public"/>
<variable name="K_5" units="per_fmol" interface="public"/>
<variable name="q_init_5" units="fmol" interface="public"/>
<variable name="K_6" units="per_fmol" interface="public"/>
<variable name="q_init_6" units="fmol" interface="public"/>
<variable name="V0_Vm" units="volt" interface="public"/>
<variable name="z_zf1" units="dimensionless" interface="public"/>
<variable name="z_zf6" units="dimensionless" interface="public"/>
<variable name="kappa_r1" units="fmol_per_s" interface="public"/>
<variable name="kappa_r2" units="fmol_per_s" interface="public"/>
<variable name="kappa_r3" units="fmol_per_s" interface="public"/>
<variable name="kappa_r4" units="fmol_per_s" interface="public"/>
<variable name="kappa_r5" units="fmol_per_s" interface="public"/>
<variable name="kappa_r6" units="fmol_per_s" interface="public"/>
<variable name="kappa_r7" units="fmol_per_s" interface="public"/>
<variable name="q_tot" units="fmol"/>
<variable name="sigma" units="dimensionless"/>
<variable name="v_max" units="fmol_per_s"/>
<variable name="v" units="fmol_per_s"/>
<variable name="v_1" units="fmol_per_s"/>
<variable name="Q_Na_o" units="dimensionless"/>
<variable name="Q_Na_i" units="dimensionless"/>
<variable name="Q_Glc_o" units="dimensionless"/>
<variable name="Q_Glc_i" units="dimensionless"/>
<variable name="z_1" units="dimensionless"/>
<variable name="z_2" units="dimensionless"/>
<variable name="B" units="dimensionless"/>
<variable name="t" units="second" interface="public"/>
<variable name="Ii" units="fA" interface="public"/>
<variable name="Ii_1" units="fA" interface="public"/>
<variable name="q_1" units="fmol"/>
<variable name="A" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML" xmlns:cellml="http://www.cellml.org/cellml/2.0#">
<apply>
<eq/>
<ci>Ii</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<plus/>
<ci>z_1</ci>
<ci>z_2</ci>
</apply>
<ci>F</ci>
<ci>v</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ii_1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<plus/>
<ci>z_1</ci>
<ci>z_2</ci>
</apply>
<ci>F</ci>
<ci>v_1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>z_1</ci>
<ci>z_zf1</ci>
</apply>
<apply>
<eq/>
<ci>z_2</ci>
<ci>z_zf6</ci>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>V0_Vm</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_tot</ci>
<apply>
<plus/>
<ci>q_init_1</ci>
<ci>q_init_2</ci>
<ci>q_init_3</ci>
<ci>q_init_4</ci>
<ci>q_init_5</ci>
<ci>q_init_6</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_max</ci>
<apply>
<times/>
<ci>q_tot</ci>
<ci>kappa_r6</ci>
<ci>K_1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_Na_o</ci>
<apply>
<times/>
<ci>K_Nao</ci>
<ci>q_Nao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_Na_i</ci>
<apply>
<times/>
<ci>K_Nai</ci>
<ci>q_Nai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_Glc_o</ci>
<apply>
<times/>
<ci>K_Glco</ci>
<ci>q_Glco</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_Glc_i</ci>
<apply>
<times/>
<ci>K_Glci</ci>
<ci>q_Glci</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>v_max</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_o</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_i</ci>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>B</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>B</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>z_1</ci>
<ci>sigma</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_2</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_3</ci>
</apply>
<ci>Q_Glc_o</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_i</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>z_2</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_6</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_5</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_4</ci>
</apply>
<ci>Q_Glc_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_o</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>z_2</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>A</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_2</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>z_1</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_3</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_o</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>z_1</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Q_Glc_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>z_2</ci>
</apply>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_4</ci>
</apply>
<ci>Q_Glc_i</ci>
</apply>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_5</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>K_1</ci>
<ci>K_6</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_o</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>z_1</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>z_2</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_1</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>q_tot</ci>
<ci>A</ci>
</apply>
<apply>
<plus/>
<ci>Q_Glc_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>z_2</ci>
</apply>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kappa_r3</ci>
<ci>K_1</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_o</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>z_1</ci>
<ci>sigma</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Q_Glc_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>z_2</ci>
</apply>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Q_Glc_i</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<ci>Q_Na_o</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>Q_Glc_o</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>z_1</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<exp/>
<apply>
<times/>
<ci>z_2</ci>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>q_1</ci>
</apply>
<apply>
<plus/>
<ci>Q_Glc_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>kappa_r6</ci>
<ci>kappa_r3</ci>
</apply>
<apply>
<power/>
<ci>Q_Na_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>z_2</ci>
</apply>
<ci>sigma</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection component_1="params_BG" component_2="SGLT1_BG">
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="K_Nai" variable_2="K_Nai"/>
<map_variables variable_1="q_Nai" variable_2="q_Nai"/>
<map_variables variable_1="K_Nao" variable_2="K_Nao"/>
<map_variables variable_1="q_Nao" variable_2="q_Nao"/>
<map_variables variable_1="K_Glci" variable_2="K_Glci"/>
<map_variables variable_1="q_Glci" variable_2="q_Glci"/>
<map_variables variable_1="K_Glco" variable_2="K_Glco"/>
<map_variables variable_1="q_Glco" variable_2="q_Glco"/>
<map_variables variable_1="K_1" variable_2="K_1"/>
<map_variables variable_1="q_init_1" variable_2="q_init_1"/>
<map_variables variable_1="K_2" variable_2="K_2"/>
<map_variables variable_1="q_init_2" variable_2="q_init_2"/>
<map_variables variable_1="K_3" variable_2="K_3"/>
<map_variables variable_1="q_init_3" variable_2="q_init_3"/>
<map_variables variable_1="K_4" variable_2="K_4"/>
<map_variables variable_1="q_init_4" variable_2="q_init_4"/>
<map_variables variable_1="K_5" variable_2="K_5"/>
<map_variables variable_1="q_init_5" variable_2="q_init_5"/>
<map_variables variable_1="K_6" variable_2="K_6"/>
<map_variables variable_1="q_init_6" variable_2="q_init_6"/>
<map_variables variable_1="V0_Vm" variable_2="V0_Vm"/>
<map_variables variable_1="z_zf1" variable_2="z_zf1"/>
<map_variables variable_1="z_zf6" variable_2="z_zf6"/>
<map_variables variable_1="kappa_r1" variable_2="kappa_r1"/>
<map_variables variable_1="kappa_r2" variable_2="kappa_r2"/>
<map_variables variable_1="kappa_r3" variable_2="kappa_r3"/>
<map_variables variable_1="kappa_r4" variable_2="kappa_r4"/>
<map_variables variable_1="kappa_r5" variable_2="kappa_r5"/>
<map_variables variable_1="kappa_r6" variable_2="kappa_r6"/>
<map_variables variable_1="kappa_r7" variable_2="kappa_r7"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
</model>
